Biopharmaceutical Chemical Compatibility
The first order of business when sterilizing and filtering an aqueous, oil, or medication is to select a filter that is chemically compatible with the solution. A great technique with excellent procedures and a “State-of-the-Art” facility will yield a failed result if the filter materials aren’t chemically compatible with the filtered solution. Usually, the membrane or seal between the membrane and filter shell is compromised when the filter materials aren’t chemically compatible with the filter solution. This yields a non-sterile product and a low bubble point when integrity testing the filter after use.
The table below isn’t a comprehensive list of all solutions that biopharmaceutical facilities use; however, it should serve as a valuable guide. We are continually revising the list. If information is needed regarding a compound or solution not found on the list below, we will try to assist by using our vast network, chemical compatibility charts for plastics used in filters or, as the last result, we can supply filters with different materials until we arrive at the correct solution.
Key:
R = Recommended, L- Limited Use, N= Not Recommended
Reference Source: Compass Publications, Chemical Resistance Guide for Plastics